Since the discovery of long-term potentiation (LTP) in 1973, thousands of papers have been
published on this intriguing phenomenon, which provides a compelling cellular model for …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

For more than 20 years, we have known that Ca2+/calmodulin-dependent protein kinase
(CaMKII) activation is both necessary and sufficient for the induction of long-term …

Long-term potentiation of synaptic transmission in the hippocampus is the primary
experimental model for investigating the synaptic basis of learning and memory in …

The synapse is the functional unit of the brain. During the last several decades we have
acquired a great deal of information on its structure, molecular components, and …

▪ Abstract Activity-dependent changes in synaptic function are believed to underlie the
formation of memories. Two prominent examples are long-term potentiation (LTP) and long …

A large body of evidence has implicated Aβ peptides and other derivatives of the amyloid
precursor protein (APP) as central to the pathogenesis of Alzheimer's disease (AD) …

It is suggested that in the brain the internal attentional searchlight, proposed by Treisman
and others, is controlled by the reticular complex of the thalamus (including the closely …

Long-term potentiation (LTP) of synaptic transmission is considered to be a cellular
counterpart of learning and memory. Activation of postsynaptic NMDA type glutamate …

▪ Abstract Dendritic spines are morphological specializations that receive synaptic inputs
and compartmentalize calcium. In spite of a long history of research, the specific function of …