The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

The circadian rhythm plays a fundamental role in regulating biological functions, including
sleep–wake preference, body temperature, hormonal secretion, food intake, and cognitive …

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …

A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …

Good sleep is essential to good health. Yet for most of its history, sleep medicine has
focused on the definition, identification, and treatment of sleep problems. Sleep health is a …

Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes∼
24 hr rhythms in many behavioral and physiological processes. This system is altered in …

Melatonin is a physiological hormone involved in sleep timing and is currently used
exogenously in the treatment of primary and secondary sleep disorders with empirical …

A systematic literature review and meta-analyses (where appropriate) were performed and
the GRADE approach was used to update the previous American Academy of Sleep …

The electric light is one of the most important human inventions. Sleep and other daily
rhythms in physiology and behavior, however, evolved in the natural light-dark cycle [1], and …

Reduced exposure to daytime sunlight and increased exposure to electrical lighting at night
leads to late circadian and sleep timing [1–3]. We have previously shown that exposure to a …