Inflammation in depression and the potential for anti-inflammatory treatment

O Kohler, J Krogh, O Mors… - Current …, 2016 - ingentaconnect.com
Accumulating evidence supports an association between depression and inflammatory
processes, a connection that seems to be bidirectional. Clinical trials have indicated …

Efficacy of anti‐inflammatory treatment on major depressive disorder or depressive symptoms: meta‐analysis of clinical trials

O Köhler‐Forsberg, C N. Lydholm… - Acta Psychiatrica …, 2019 - Wiley Online Library
Background No study has gathered evidence from all randomized clinical trials (RCT s) with
anti‐inflammatory drugs measuring antidepressant effects including a detailed assessment …

Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials

S Bai, W Guo, Y Feng, H Deng, G Li, H Nie… - Journal of Neurology …, 2020 - jnnp.bmj.com
Objectives To systematically review the efficacy and safety of anti-inflammatory agents for
patients with major depressive disorders. Methods We searched the literature to identify …

Cognitive remission: a novel objective for the treatment of major depression?

B Bortolato, KW Miskowiak, CA Köhler, M Maes… - BMC medicine, 2016 - Springer
Background Cognitive dysfunction in major depressive disorder (MDD) encompasses
several domains, including but not limited to executive function, verbal memory, and …

Statins and inflammation: new therapeutic opportunities in psychiatry

SW Kim, HJ Kang, M Jhon, JW Kim, JY Lee… - Frontiers in …, 2019 - frontiersin.org
Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and
anti-oxidant effects. These are thought to be responsible for the potential effects of statins on …

Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders

LGP de Melo, SOV Nunes, G Anderson… - Progress in Neuro …, 2017 - Elsevier
This review examines the shared immune-inflammatory, oxidative and nitrosative stress
(IO&NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder …

Therapeutic strategies for treatment of inflammation-related depression

M Adzic, Z Brkic, M Mitic, E Francija… - Current …, 2018 - ingentaconnect.com
Background: Mounting evidence demonstrates enhanced systemic levels of inflammatory
mediators in depression, indicating that inflammation may play a role in the etiology and …

Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress

J Sun, F Wang, G Hong, M Pang, H Xu, H Li, F Tian… - Neuroscience …, 2016 - Elsevier
Sodium butyrate (NaB) has exhibited neuroprotective activity. This study aimed to explore
that NaB exerts beneficial effects on chronic unpredictable mild stress (CUMS)-induced …

Depression clinical trials worldwide: a systematic analysis of the ICTRP and comparison with ClinicalTrials. gov

ED Namiot, D Smirnovová, AV Sokolov… - Translational …, 2024 - nature.com
Major depressive disorder (MDD), commonly known as depression, affects over 300 million
people worldwide as of 2018 and presents a wide range of clinical symptoms. The …