Cellular specialization is particularly prominent in mammalian nervous systems, which are
composed of millions to billions of neurons that appear in thousands of different'flavors' and …

Local translation in neuronal processes is key to the alteration of synaptic strength
necessary for long-term potentiation, learning, and memory. Here, we present evidence that …

In neurons, dendritic protein synthesis is required for many forms of long-term synaptic
plasticity. The population of mRNAs that are localized to dendrites, however, remains …

Clarifying gene expression in narrowly defined neuronal populations can provide insight
into cellular identity, computation, and functionality. Here, we used next-generation RNA …

Traditionally, neuroscientists have defined the identity of neurons by the cells' location,
morphology, connectivity and excitability. However, the direct relationship between these …

The influence that neurons exert on astrocytic function is poorly understood. To investigate
this, we first developed a system combining cortical neurons and astrocytes from closely …

In humans and other mammalian species, lesions in the preoptic area of the hypothalamus
cause profound sleep impairment,,,,, indicating a crucial role of the preoptic area in sleep …

Microglia, brain-resident macrophages, require instruction from the CNS microenvironment
to maintain their identity and morphology and regulate inflammatory responses, although …

Molecular and cellular processes in neurons are critical for sensing and responding to
energy deficit states, such as during weight-loss. Agouti related protein (AGRP)-expressing …

Transcriptome profiling of single cells resident in their natural microenvironment depends
upon RNA capture methods that are both noninvasive and spatially precise. We engineered …