Although hormones such as glucocorticoids have been broadly accepted in recent decades
as general neuromodulators of memory processes, sex steroid hormones such as the potent …

Estrogen receptor β (ERβ) is closely related to breast cancer (BC) progression. Traditional
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …

Substituted six-membered cyclic hydrocarbons are common constituents of biologically
active compounds. Although methods for the synthesis of thermodynamically favored …

The sex steroid hormones (SSHs) play several roles in regulation of various processes in
the cardiovascular, immune, muscular and neural systems. SSHs affect prenatal and …

The phenyl ring is a basic structural element in chemistry. Here, we show the design,
synthesis, and validation of its new saturated bioisostere with improved physicochemical …

S-equol, a metabolite of soy isoflavone daidzein transformed by the gut microbiome, is the
most biologically potent among all soy isoflavones and their metabolites. Soy isoflavones …

Introduction Alzheimer's disease (AD) prevalence and severity are associated with
increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen …

The consolidation of long-term memory is influenced by various neuromodulators. One of
these is estradiol, a steroid hormone that is synthesized both in peripheral endocrine tissue …

Estrogen regulates a plethora of biological processes, under physiological and pathological
conditions, by affecting key pathways involved in the regulation of cell proliferation, fate …

Abstract Development of estrogen therapies targeting the β (ERβ) but not α (ERα) estrogen
receptor is critically needed for the treatment of negative menopausal symptoms, as ERα …