Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …

Cancer stemness, defined as the self-renewal and tumor-initiation potential of cancer stem
cells (CSCs), is a cancer biology property featuring activation of CSC signaling networks …

Abstract KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among
the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how …

Phenotypic plasticity associated with the hybrid epithelial–mesenchymal transition (EMT) is
crucial to metastatic seeding and outgrowth. However, the mechanisms governing the hybrid …

Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …

Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in
embryonic development, wound-healing, and immune homeostasis. Yet, during tumor …

Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …

Epithelial–mesenchymal transition (EMT) is a cellular process involved in many
physiological and pathological conditions. However, in the last decade there has been a …

In metastasis, cancer cells travel around the circulation to colonize distant sites. Due to the
rarity of these events, the immediate fates of metastasizing tumor cells (mTCs) are poorly …

Integrating diverse types of biological data is essential for a holistic understanding of cancer
biology, yet it remains challenging due to data heterogeneity, complexity, and sparsity …