Neurobiology of schizophrenia
CA Ross, RL Margolis, SAJ Reading, M Pletnikov… - Neuron, 2006 - cell.com
With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia
affects the most basic human processes of perception, emotion, and judgment. Evidence …
affects the most basic human processes of perception, emotion, and judgment. Evidence …
Adult neurogenesis and psychiatric disorders
Psychiatric disorders continue to be among the most challenging disorders to diagnose and
treat because there is no single genetic or anatomical locus that is causative for the disease …
treat because there is no single genetic or anatomical locus that is causative for the disease …
Long neural genes harbor recurrent DNA break clusters in neural stem/progenitor cells
Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for
neural development, and brain cells frequently contain somatic genomic variations that …
neural development, and brain cells frequently contain somatic genomic variations that …
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N= 53 949)
General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this …
adolescence to old age. We investigated the genetic contribution to variation in this …
Discovery of a proneurogenic, neuroprotective chemical
AA Pieper, S **e, E Capota, SJ Estill, J Zhong, JM Long… - Cell, 2010 - cell.com
An in vivo screen was performed in search of chemicals capable of enhancing neuron
formation in the hippocampus of adult mice. Eight of 1000 small molecules tested enhanced …
formation in the hippocampus of adult mice. Eight of 1000 small molecules tested enhanced …
Protein misfolding and aggregation in the brain: common pathogenetic pathways in neurodegenerative and mental disorders
A Ochneva, Y Zorkina, O Abramova, O Pavlova… - International journal of …, 2022 - mdpi.com
Mental disorders represent common brain diseases characterized by substantial
impairments of social and cognitive functions. The neurobiological causes and mechanisms …
impairments of social and cognitive functions. The neurobiological causes and mechanisms …
Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders
J Sebat, DL Levy, SE McCarthy - Trends in Genetics, 2009 - cell.com
Recent studies have established an important role for rare genomic deletions and
duplications in the etiology of schizophrenia. This research suggests that the genetic …
duplications in the etiology of schizophrenia. This research suggests that the genetic …
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
Objective: Family and twin studies indicate substantial overlap of genetic influences on
psychotic and mood disorders. Linkage and candidate gene studies have also suggested …
psychotic and mood disorders. Linkage and candidate gene studies have also suggested …
Glutamate signaling in the pathophysiology and therapy of schizophrenia
Glutamatergic neurotransmission, particularly through the N-methyl-d-aspartate (NMDA)
receptor, has drawn attention for its role in the pathophysiology of schizophrenia. This paper …
receptor, has drawn attention for its role in the pathophysiology of schizophrenia. This paper …
Human accelerated regions and other human-specific sequence variations in the context of evolution and their relevance for brain development
A Levchenko, A Kanapin, A Samsonova… - Genome biology and …, 2018 - academic.oup.com
The review discusses, in a format of a timeline, the studies of different types of genetic
variants, present in Homo sapiens, but absent in all other primate, mammalian, or vertebrate …
variants, present in Homo sapiens, but absent in all other primate, mammalian, or vertebrate …