[HTML][HTML] Insulin/insulin-like growth factor signaling in C. elegans
The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …
growth, development, longevity, and behavior. This fundamental pathway is regulated by …
Caught up in a Wnt storm: Wnt signaling in cancer
The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …
various differentiation events during embryonic development and leads to tumor formation …
Three decades of Wnts: a personal perspective on how a scientific field developed
Wnt genes and components of Wnt signalling pathways have been implicated in a wide
spectrum of important biological phenomena, ranging from early organismal development to …
spectrum of important biological phenomena, ranging from early organismal development to …
Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus
The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in
directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt …
directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt …
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca2+ pathway to antagonize Wnt/β-catenin signaling
Wnt signaling controls a variety of developmental processes. The canonical Wnt/β-catenin
pathway functions to stabilize β-catenin, and the noncanonical Wnt/Ca 2+ pathway activates …
pathway functions to stabilize β-catenin, and the noncanonical Wnt/Ca 2+ pathway activates …
[HTML][HTML] The p300/CBP acetyltransferases function as transcriptional coactivators of β‐catenin in vertebrates
A Hecht, K Vleminckx, MP Stemmler, F Van Roy… - The EMBO …, 2000 - embopress.org
Wnt growth factors regulate a variety of developmental processes by altering specific gene
expression patterns. In vertebrates β‐catenin acts as transcriptional activator, which is …
expression patterns. In vertebrates β‐catenin acts as transcriptional activator, which is …
Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
Communication between cells is often mediated by secreted signaling molecules that bind
cell surface receptors and modulate the activity of specific intracellular effectors. The Wnt …
cell surface receptors and modulate the activity of specific intracellular effectors. The Wnt …
β-catenin defines head versus tail identity during planarian regeneration and homeostasis
After amputation, freshwater planarians properly regenerate a head or tail from the resulting
anterior or posterior wound. The mechanisms that differentiate anterior from posterior and …
anterior or posterior wound. The mechanisms that differentiate anterior from posterior and …
[HTML][HTML] Atypical mitogen-activated protein kinases: structure, regulation and functions
Mitogen-activated protein (MAP) kinases are a family of serine/threonine kinases that play a
central role in transducing extracellular cues into a variety of intracellular responses ranging …
central role in transducing extracellular cues into a variety of intracellular responses ranging …
Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos
Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps
during earlydevelopment. In this review, we discuss processes that set up the embryonic …
during earlydevelopment. In this review, we discuss processes that set up the embryonic …