Genome-scale models in human metabologenomics

A Mardinoglu, BØ Palsson - Nature Reviews Genetics, 2025 - nature.com
Metabologenomics integrates metabolomics with other omics data types to comprehensively
study the genetic and environmental factors that influence metabolism. These multi-omics …

State-of the-art constraint-based modeling of microbial metabolism: from basics to context-specific models with a focus on methanotrophs

MA Kulyashov, SK Kolmykov, TM Khlebodarova… - Microorganisms, 2023 - mdpi.com
Methanotrophy is the ability of an organism to capture and utilize the greenhouse gas,
methane, as a source of energy-rich carbon. Over the years, significant progress has been …

pan-Draft: automated reconstruction of species-representative metabolic models from multiple genomes

N De Bernardini, G Zampieri, S Campanaro… - Genome Biology, 2024 - Springer
The accurate reconstruction of genome-scale metabolic models (GEMs) for unculturable
species poses challenges due to the incomplete and fragmented genetic information typical …

Transporter annotations are holding up progress in metabolic modeling

J Casey, B Bennion, P D'haeseleer… - Frontiers in Systems …, 2024 - frontiersin.org
Mechanistic, constraint-based models of microbial isolates or communities are a staple in
the metabolic analysis toolbox, but predictions about microbe-microbe and microbe …

Emerging methods for genome-scale metabolic modeling of microbial communities

C Tarzi, G Zampieri, N Sullivan, C Angione - Trends in Endocrinology & …, 2024 - cell.com
Genome-scale metabolic models (GEMs) are consolidating as platforms for studying mixed
microbial populations, by combining biological data and knowledge with mathematical rigor …

A review and prospects: Multi-omics and artificial intelligence-based approaches to understanding the effects of lactic acid bacteria and yeast interactions on …

J Yuan, D Ma, Y Yang, Y Zhao, H Ren, X Liu… - Innovative Food Science …, 2024 - Elsevier
There are numerous reports on the effect of co-culturing lactic acid bacteria (LAB) and yeast
on the quality of fermented foods. The interactions between LAB and yeast affect the flavour …

Metabolic model-based ecological modeling for probiotic design

JD Brunner, N Chia - Elife, 2024 - elifesciences.org
The microbial community composition in the human gut has a profound effect on human
health. This observation has lead to extensive use of microbiome therapies, including over …

[HTML][HTML] Genomic Science Program US Department of Energy| Office of Science| Biological and Environmental Research Program

R Murali, V Orphan - genomicscience.energy.gov
Most elemental cycles in Earth's surface environment are mediated by microbial reactions.
To quantify these transformations and predict the distribution of nutrients and other …