Perturbations in metabolic pathways can cause substantial increases in plasma and tissue
concentrations of long-chain acylcarnitines (LCACs). For example, the levels of LCACs and …

Skeletal and cardiac muscles play key roles in the regulation of systemic energy
homeostasis and display remarkable plasticity in their metabolic responses to caloric …

Mitochondria play an integral role in cell death, autophagy, immunity, and inflammation. We
previously showed that Nur77, an orphan nuclear receptor, induces apoptosis by targeting …

We review mechanisms that regulate production of glucose by the liver, focusing on areas of
budding consensus, and endeavoring to provide a candid assessment of lingering …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, but their
molecular etiology remains poorly understood, in part because they develop slowly as a …

Numerous members of the nuclear hormone receptor (NR) superfamily have been
demonstrated to regulate metabolic function in a cell-and tissue-specific manner. This …

As a classically known mitogen, fibroblast growth factor 1 (FGF1) has been found to exert
other pleiotropic functions such as metabolic regulation and myocardial protection. Here, we …

Insulin resistance (IR), a key component of the metabolic syndrome, precedes the
development of diabetes, cardiovascular disease, and Alzheimer's disease. Its etiological …

The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …

The interplay of the immune system with other aspects of physiology is continually being
revealed and in some cases studied in considerable mechanistic detail. A prime example is …