Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
SE Polo, SP Jackson - Genes & development, 2011 - genesdev.cshlp.org
Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …
termed the DNA damage response (DDR). A common feature of DDR proteins is their …
[HTML][HTML] Chromatin remodeling at DNA double-strand breaks
BD Price, AD D'Andrea - Cell, 2013 - cell.com
DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to
ionizing radiation. The repair of DSBs involves both posttranslational modification of …
ionizing radiation. The repair of DSBs involves both posttranslational modification of …
H2AX phosphorylation: its role in DNA damage response and cancer therapy
M Podhorecka, A Skladanowski… - Journal of nucleic …, 2010 - Wiley Online Library
Double‐strand breaks (DSBs) are the most deleterious DNA lesions, which, if left
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
J Lukas, C Lukas, J Bartek - Nature cell biology, 2011 - nature.com
Following the discovery in 1998 of γ-H2AX, the first histone modification induced by DNA
damage, interest in the changes to chromatin induced by DNA damage has exploded, and a …
damage, interest in the changes to chromatin induced by DNA damage has exploded, and a …
Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair
Double-strand breaks (DSBs) in heterochromatic repetitive DNAs pose significant threats to
genome integrity, but information about how such lesions are processed and repaired is …
genome integrity, but information about how such lesions are processed and repaired is …
DNA damage response
G Giglia-Mari, A Zotter… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Structural changes to DNA severely affect its functions, such as replication and transcription,
and play a major role in age-related diseases and cancer. A complicated and entangled …
and play a major role in age-related diseases and cancer. A complicated and entangled …
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin
MK Ayrapetov, O Gursoy-Yuzugullu… - Proceedings of the …, 2014 - National Acad Sciences
Dynamic changes in histone modification are critical for regulating DNA double-strand break
(DSB) repair. Activation of the Tip60 acetyltransferase by DSBs requires interaction of Tip60 …
(DSB) repair. Activation of the Tip60 acetyltransferase by DSBs requires interaction of Tip60 …
End-joining, translocations and cancer
SF Bunting, A Nussenzweig - Nature Reviews Cancer, 2013 - nature.com
Fusion genes that are caused by chromosome translocations have been recognized for
several decades as drivers of deregulated cell growth in certain types of cancer. In recent …
several decades as drivers of deregulated cell growth in certain types of cancer. In recent …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
Immediate-early, early, and late responses to DNA double stranded breaks
SR Kieffer, NF Lowndes - Frontiers in Genetics, 2022 - frontiersin.org
Loss or rearrangement of genetic information can result from incorrect responses to DNA
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …