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PGC-1α is a master regulator of mitochondrial lifecycle and ROS stress response
Mitochondria play a major role in ROS production and defense during their life cycle. The
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …
PGC‐1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism
S Rius-Pérez, I Torres-Cuevas, I Millán… - Oxidative medicine …, 2020 - Wiley Online Library
Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …
coactivator described as a master regulator of mitochondrial biogenesis and function …
High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms
CY Lian, ZZ Zhai, ZF Li, L Wang - Chemico-biological interactions, 2020 - Elsevier
Obesity is characterized by the deposition of excessive body fat, and is caused by energy
imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity …
imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity …
NAFLD as a sexual dimorphic disease: role of gender and reproductive status in the development and progression of nonalcoholic fatty liver disease and inherent …
Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic
steatohepatis, cirrhosis, and hepatocellular carcinoma (HCC) associated with striking …
steatohepatis, cirrhosis, and hepatocellular carcinoma (HCC) associated with striking …
Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue
Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease
A Cherubini, S Della Torre, S Pelusi… - Trends in Molecular …, 2024 - cell.com
Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common
chronic liver condition. MASLD is a sexually dimorphic condition, with its development and …
chronic liver condition. MASLD is a sexually dimorphic condition, with its development and …
[HTML][HTML] Mitochondria in non-alcoholic fatty liver disease
NAFLD is a common disease in Western society and ranges from steatosis to steatohepatitis
and to end-stage liver disease. The molecular mechanisms that cause the progression of …
and to end-stage liver disease. The molecular mechanisms that cause the progression of …
Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators
Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …
The role and mechanism of oxidative stress and nuclear receptors in the development of NAFLD
T Hong, Y Chen, X Li, Y Lu - Oxidative medicine and cellular …, 2021 - Wiley Online Library
The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
Critical role of estrogen in the progression of chronic liver diseases
Background Estrogens regulate sexual function and also have a significant role in various
pathophysiological processes. Estrogens have a non-reproductive role as the modulators of …
pathophysiological processes. Estrogens have a non-reproductive role as the modulators of …