The most widespread intracellular bacteria in the animal kingdom are maternally inherited
endosymbionts of the genus Wolbachia. Their prevalence in arthropods and nematodes …

Background Wolbachia is an obligate intracellular maternally transmitted, gram-negative
bacterium which forms a spectrum of endosymbiotic relationships from parasitism to …

The use of alternative (or complementary) treatment strategies (ATSs) ie differing from
annual community-directed treatment with ivermectin (CDTI) is required in some African foci …

Although lymphatic filariasis and onchocerciasis have been targeted for global elimination,
these helminth infections are still a major public health problem across the tropics and …

Neglected tropical diseases (NTDs) and other diseases of the develo** world, such as
malaria, attract research investments that are disproportionately low compared to their …

The mutualistic association between Wolbachia endosymbionts and their filarial nematode
hosts has been exploited as a validated drug target delivering macrofilaricidal outcomes …

There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the
neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective …

Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together
affect∼ 157 million people and inflict severe disability. Both diseases are caused by …

Brugia malayi are thread-like parasitic worms and one of the etiological agents of Lymphatic
filariasis (LF). Existing anthelmintic drugs to treat LF are effective in reducing the larval …

Twenty diseases are recognized as neglected tropical diseases (NTDs) by World Health
Assembly resolutions, including human filarial diseases. The end of NTDs is embedded …