Irisin: a promising treatment for neurodegenerative diseases

J Qi, L Yang, X Wang, M Wang, X Li, B Feng, Y Wu… - Neuroscience, 2022 - Elsevier
The beneficial effects of exercise on human brain function have been demonstrated in
previous studies. Myokines secreted by muscle have attracted increasing attention because …

Exercise-produced irisin effects on brain-related pathological conditions

RAL De Sousa - Metabolic Brain Disease, 2024 - Springer
Exercise increases peroxisome proliferator-activated receptor-gamma coactivator 1-alpha
(PGC-1α) expression, which in turn causes the fibronectin type III domain containing 5 …

Nesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure

SA Tamer, T Koyuncuoğlu, AK Köroğlu, D Akakın… - Life Sciences, 2022 - Elsevier
Aims We aimed to investigate putative neuroprotective effects of nesfatin-1 on oxidative
brain injury and memory dysfunction induced by a single epileptic seizure and to compare …

Evaluation of repeated ghrelin administration on seizures, oxidative stress and neurochemical parameters in pentyleneterazole induced kindling in rats

O Ergul Erkec, O Yunusoglu, Z Huyut - International Journal of …, 2024 - Taylor & Francis
Introduction: Epileptic seizures are thought to be caused by the impaired balance between
excitatory (glutamate) and inhibitor [gamma amino butyric acid (GABA)] neurotransmitters in …

Targeting the ghrelin receptor as a novel therapeutic option for epilepsy

A Buckinx, D De Bundel, R Kooijman, I Smolders - Biomedicines, 2021 - mdpi.com
Epilepsy is a neurological disease affecting more than 50 million individuals worldwide.
Notwithstanding the availability of a broad array of antiseizure drugs (ASDs), 30% of patients …

Down regulation of the hippocampal ghrelin receptor type-1a during electrical kindling-induced epileptogenesis

M Azimzadeh, S Beheshti - Epilepsy Research, 2023 - Elsevier
Numerous studies have shown that the ghrelin hormone is involved in epileptic conditions.
However, the profile of ghrelin or its functional receptor mRNAs in seizure-susceptible brain …

Intracerebroventricular administration of the exercise hormone irisin or acute strenuous exercise alleviates epileptic seizure-induced neuroinflammation and improves …

ZN Ozdemir-Kumral, T Akgün, C Haşim, E Ulusoy… - BMC neuroscience, 2024 - Springer
Background Status epilepticus is a common and potentially life-threatening neurological
emergency with a high risk for cognitive and neurobiological impairment. Our aim was to …

Antagonism of the ghrelin receptor type 1a in the rat brain induces status epilepticus in an electrical kindling model of epilepsy

M Azimzadeh, S Beheshti - Psychopharmacology, 2022 - Springer
Studies have shown the anti-seizure properties of the ghrelin hormone in different models of
epilepsy. Nevertheless, the role of the endogenous ghrelin is unknown in the electrical …

Nesfatin-1 exerts anticonvulsant effect by reducing oxidative stress in experimental epilepsy model

S Keloglan, F AYÇIK, S Kocacan… - Acta neurobiologiae …, 2023 - avesis.omu.edu.tr
Neuropeptides play an important role in the pathogenesis of epilepsy. In the present study,
the effect of nesfatin-1, a neuropeptide, was investigated on penicillin-induced epilepsy …

Evaluation of serum ghrelin, nesfatin-1, irisin, and vasoactive intestinal peptide levels in temporal lobe epilepsy patients with and without drug resistance: a cross …

OE Erkec, A Milanlıoğlu, AU Komuroglu… - Revista da Associação …, 2021 - SciELO Brasil
SUMMARY OBJECTIVE: Epilepsy is a common disorder that affects the nervous systems of
1% of worldwide population. In epilepsy, one-third of patients are unresponsive to current …