Mechanism of deep brain stimulation: inhibition, excitation, or disruption?

S Chiken, A Nambu - The neuroscientist, 2016 - journals.sagepub.com
Deep brain stimulation (DBS), applying high-frequency electrical stimulation to deep brain
structures, has now provided an effective therapeutic option for treatment of various …

Network perspectives on the mechanisms of deep brain stimulation

CC McIntyre, PJ Hahn - Neurobiology of disease, 2010 - Elsevier
Deep brain stimulation (DBS) is an established medical therapy for the treatment of
movement disorders and shows great promise for several other neurological disorders …

An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology

AM Aravanis, LP Wang, F Zhang… - Journal of neural …, 2007 - iopscience.iop.org
Neural interface technology has made enormous strides in recent years but stimulating
electrodes remain incapable of reliably targeting specific cell types (eg excitatory or …

Alterations in neuronal activity in basal ganglia-thalamocortical circuits in the parkinsonian state

A Galvan, A Devergnas, T Wichmann - Frontiers in neuroanatomy, 2015 - frontiersin.org
In patients with Parkinson's disease and in animal models of this disorder, neurons in the
basal ganglia and related regions in thalamus and cortex show changes that can be …

The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism

C Wiest, F Torrecillos, A Pogosyan, M Bange… - elife, 2023 - elifesciences.org
Periodic features of neural time-series data, such as local field potentials (LFPs), are often
quantified using power spectra. While the aperiodic exponent of spectra is typically …

[HTML][HTML] Mechanisms and targets of deep brain stimulation in movement disorders

MD Johnson, S Miocinovic, CC McIntyre, JL Vitek - Neurotherapeutics, 2008 - Elsevier
Chronic electrical stimulation of the brain, known as deep brain stimulation (DBS), has
become a preferred surgical treatment for medication-refractory movement disorders …

Frequency-specific optogenetic deep brain stimulation of subthalamic nucleus improves parkinsonian motor behaviors

C Yu, IR Cassar, J Sambangi… - Journal of Neuroscience, 2020 - Soc Neuroscience
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy for the
motor symptoms of Parkinson's disease (PD). However, the neural elements mediating …

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation

S Li, GW Arbuthnott, MJ Jutras… - Journal of …, 2007 - journals.physiology.org
Deep brain stimulation (DBS) is an effective treatment of Parkinson's disease (PD) for many
patients. The most effective stimulation consists of high-frequency biphasic stimulation …

Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns

GC McConnell, RQ So, JD Hilliard… - Journal of …, 2012 - Soc Neuroscience
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for
the motor symptoms of Parkinson's disease (PD). The effects of DBS depend strongly on …

Deep brain stimulation mechanisms: beyond the concept of local functional inhibition

JM Deniau, B Degos, C Bosch… - European Journal of …, 2010 - Wiley Online Library
Deep brain electrical stimulation has become a recognized therapy in the treatment of a
variety of motor disorders and has potentially promising applications in a wide range of …