Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Genome-wide association studies have yielded thousands of associations for many
common diseases and disease-related complex traits. The identified associations made it …

The number of Mendelian randomization (MR) analyses including large numbers of genetic
variants is rapidly increasing. This is due to the proliferation of genome‐wide association …

Mendelian randomization refers to an analytic approach to assess the causality of an
observed association between a modifiable exposure or risk factor and a clinically relevant …

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides
thorough coverage of the methods and practical elements of Mendelian randomization …

Instrumental variable analysis is an approach for obtaining causal inferences on the effect of
an exposure (risk factor) on an outcome from observational data. It has gained in popularity …

We give critical attention to the assumptions underlying Mendelian randomization analysis
and their biological plausibility. Several scenarios violating the Mendelian randomization …

Presents the Terminology and Methods of Mendelian Randomization for Epidemiological
StudiesMendelian randomization uses genetic instrumental variables to make inferences …

Background: Sample size calculations are an important tool for planning epidemiological
studies. Large sample sizes are often required in Mendelian randomization investigations …

Abstract Background Mendelian Randomization (MR) studies assess the causality of an
exposure–disease association using genetic determinants [ie instrumental variables (IVs)] of …