The number of animals used in research has increased with the advancement of research
and development in medical technology. Every year, millions of experimental animals are …

In vivo models remain a principle screening tool in the drug discovery pipeline. Here, the
challenges associated with the need for animal experiments, as well as their impact on …

Background Budding yeast, S. cerevisiae, has been used extensively as a model organism
for studying cellular processes in evolutionarily distant species, including humans. However …

Pathophysiological damages and loss of function of dopamine neurons precede their
demise and contribute to the early phases of Parkinson's disease. The presence of aberrant …

Huntington's disease (HD) is a neurodegenerative disorder that leads to progressive
neuronal loss, provoking impaired motor control, cognitive decline, and dementia. So far, HD …

Abstract Amyotrophic Lateral Sclerosis is a progressive, incurable amyloid aggregating
neurodegenerative disease involving the motor neurons. Identifying potential biomarkers …

Protein quality control (PQC) is critical to maintain a functioning proteome. Misfolded or toxic
proteins are either refolded or degraded by a system of temporal quality control and can also …

Alzheimer's disease is the most common neurodegenerative disorder. One of the factors that
promotes neurodegeneration is the accumulation of senile plaques formed by Aβ peptide. In …

Neurodegenerative disorders have a profound effect on the quality of life of patients and
their environment. However, the development of adequate therapies requires accurate …

Abstract Alzheimer's disease (AD), and many neurodegenerative disorders, are
multifactorial in nature. They involve a combination of genomic, epigenomic, interactomic …