Genetic and hormonal mechanisms underlying sex-specific immune responses in tuberculosis
Tuberculosis (TB), the world's deadliest bacterial infection, afflicts more human males than
females, with a male/female (M/F) ratio of 1.7. Sex disparities in TB prevalence …
females, with a male/female (M/F) ratio of 1.7. Sex disparities in TB prevalence …
Natural and trained innate immunity against Mycobacterium tuberculosis
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, remains a major
global health emergency. It is estimated that one third of global population are affected …
global health emergency. It is estimated that one third of global population are affected …
Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19
Background There is a growing literature on the association of SARS-CoV-2 and other
chronic conditions, such as noncommunicable diseases. However, little is known about the …
chronic conditions, such as noncommunicable diseases. However, little is known about the …
Phosphorylation and signal transduction pathways in translational control
CG Proud - Cold Spring Harbor perspectives in biology, 2019 - cshperspectives.cshlp.org
Protein synthesis, including the translation of specific messenger RNAs (mRNAs), is
regulated by extracellular stimuli such as hormones and by the levels of certain nutrients …
regulated by extracellular stimuli such as hormones and by the levels of certain nutrients …
Host sirtuin 2 as an immunotherapeutic target against tuberculosis
Mycobacterium tuberculosis (Mtb) employs plethora of mechanisms to hijack the host
defence machinery for its successful survival, proliferation and persistence. Here, we show …
defence machinery for its successful survival, proliferation and persistence. Here, we show …
Platelet activation and the immune response to tuberculosis
In 2019 10 million people developed symptomatic tuberculosis (TB) disease and 1.2 million
died. In active TB the inflammatory response causes tissue destruction, which leads to both …
died. In active TB the inflammatory response causes tissue destruction, which leads to both …
Regulation and repurposing of nutrient sensing and autophagy in innate immunity
J Sanchez-Garrido, AR Shenoy - Autophagy, 2021 - Taylor & Francis
Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability
promotes cell growth and proliferation and suppresses catabolic processes, such as …
promotes cell growth and proliferation and suppresses catabolic processes, such as …
Breaking the Cycle: Matrix Metalloproteinase Inhibitors as an Alternative Approach in Managing Tuberculosis Pathogenesis and Progression
Mycobacterium tuberculosis (Mtb) has long posed a significant challenge to global public
health, resulting in approximately 1.6 million deaths annually. Pulmonary tuberculosis (TB) …
health, resulting in approximately 1.6 million deaths annually. Pulmonary tuberculosis (TB) …
Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) remains a grave threat to world health with emerging drug
resistant strains. One prominent feature of Mtb infection is the extensive reprogramming of …
resistant strains. One prominent feature of Mtb infection is the extensive reprogramming of …
A novel role for C–C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis
C–C motif chemokine receptor 2 (CCR2) is a major chemokine axis that recruits myeloid
cells including monocytes and macrophages. Thus far, CCR2−/− mice have not been found …
cells including monocytes and macrophages. Thus far, CCR2−/− mice have not been found …