Reframing sexual differentiation of the brain

MM McCarthy, AP Arnold - Nature neuroscience, 2011‏ - nature.com
In the twentieth century, the dominant model of sexual differentiation stated that genetic sex
(XX versus XY) causes differentiation of the gonads, which then secrete gonadal hormones …

Synthesizing views to understand sex differences in response to early life adversity

KG Bath - Trends in Neurosciences, 2020‏ - cell.com
Sex as a biological variable (SABV) is critical for understanding the broad range of
physiological, neurobiological, and behavioral consequences of early life adversity (ELA) …

Sex differences in epigenetic regulation of the estrogen receptor-α promoter within the develo** preoptic area

JR Kurian, KM Olesen, AP Auger - Endocrinology, 2010‏ - academic.oup.com
Sex differences in the brain are largely organized by a testicular hormone surge that occurs
in males shortly after birth. Although this hormone surge is transient, sex differences in brain …

The complex relationships between sex and the brain

D Joel, A Garcia-Falgueras, D Swaab - The Neuroscientist, 2020‏ - journals.sagepub.com
In the past decennia, our understanding of the sexual differentiation of the mammalian brain
has dramatically changed. The simple model according to which testosterone masculinizes …

Maternal influences on the sexual behavior and reproductive success of the female rat

NM Cameron, EW Fish, MJ Meaney - Hormones and behavior, 2008‏ - Elsevier
In many species, including humans, there is evidence for parental effects on within-sex
variations in reproductive behavior. In the present studies we found that variations in …

Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system

NG Forger, JA Strahan, A Castillo-Ruiz - Frontiers in neuroendocrinology, 2016‏ - Elsevier
Neuroscientists are likely to discover new sex differences in the coming years, spurred by
the National Institutes of Health initiative to include both sexes in preclinical studies. This …

Experience-dependent plasticity drives individual differences in pheromone-sensing neurons

PS Xu, D Lee, TE Holy - Neuron, 2016‏ - cell.com
Different individuals exhibit distinct behaviors, but studying the neuronal basis of
individuality is a daunting challenge. Here, we considered this question in the vomeronasal …

The spinal nucleus of the bulbocavernosus: firsts in androgen-dependent neural sex differences

DR Sengelaub, NG Forger - Hormones and behavior, 2008‏ - Elsevier
Cell number in the spinal nucleus of the bulbocavernosus (SNB) of rats was the first neural
sex difference shown to differentiate under the control of androgens, acting via classical …

Is it useful to view the brain as a secondary sexual characteristic?

GF Ball, J Balthazart, MM McCarthy - Neuroscience & Biobehavioral …, 2014‏ - Elsevier
Many sex differences in brain and behavior related to reproduction are thought to have
evolved based on sexual selection involving direct competition for mates during male–male …

[HTML][HTML] Sexes on the brain: Sex as multiple biological variables in the neuronal control of feeding

MG Massa, SM Correa - Biochimica et Biophysica Acta (BBA)-Molecular …, 2020‏ - Elsevier
Neuronal interactions at the level of vagal, homeostatic, and hedonic circuitry work to
regulate the neuronal control of feeding. This integrative system appears to vary across sex …