Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …

Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …

Nearly two decades have passed since it was first proposed that regulation of the
interconvertible sphingolipid metabolites, ceramide and sphingosine-1-phosphate (S1P) …

Abstract Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors
(S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …

Sphingosine kinases (isoforms SK1 and SK2) catalyse the formation of a bioactive lipid,
sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P …

Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

Background The greatest genetic risk factor for late-onset Alzheimer's disease (AD) is the ϵ4
allele of Apolipoprotein E (ApoE). ApoE regulates secretion of the potent neuroprotective …

Sphingosine kinase 1 (SphK1) a key enzyme that catalyzes the conversion of sphingosine
(Sph) to sphingosine 1-phosphate (S1P), so as to maintain the dynamic balance of …

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts either as an
intracellular messenger or as a ligand for its membrane receptors. S1P is a normal …