The modern biopharmaceutical industry traces its roots to the dawn of the twentieth century,
coincident with marketing of aspirin—a signature event in the history of modern drug …

Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking
between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries …

Summary β-Coronaviruses are a family of positive-strand enveloped RNA viruses that
includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is …

Triacylglycerols (TAGs) are the main source of stored energy in the body, providing an
important substrate pool for mitochondrial beta-oxidation. Imbalances in the amount of TAGs …

Autophagosome formation requires sequential translocation of autophagy-specific proteins
to membranes enriched in PI3P and connected to the ER. Preceding this, the earliest …

Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the
endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha …

Background & Aims Chronic alcohol consumption is a leading risk factor for the
development of hepatocellular carcinoma (HCC), which is associated with a marked …

The Golgi is a membrane-bound organelle that is essential for protein and lipid biosynthesis.
It represents a central trafficking hub that sorts proteins and lipids to various destinations or …

Abbreviations used in this paper: ANOVA, analysis of variance; FKBP, FK506 binding
protein; FRB, FKBP12-rapamycin binding; iRFP, infra-RFP; nMDP, normalized mean …

Dying tumour cells can elicit a potent anticancer immune response by exposing the
calreticulin (CRT)/ERp57 complex on the cell surface before the cells manifest any signs of …