Even when split into several chromosomes, DNA molecules that make up our genome are
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …

Advances in microscopy and genomic techniques have provided new insight into spatial
chromatin organization inside of the nucleus. In particular, chromosome conformation …

Chromatin has a complex spatial organization in the cell nucleus that serves vital functional
purposes. A variety of chromatin folding conformations has been detected by single-cell …

The fractal globule is a compact polymer state that emerges during polymer condensation as
a result of topological constraints which prevent one region of the chain from passing across …

During interphase chromosomes decondense, but fluorescent in situ hybridization
experiments reveal the existence of distinct territories occupied by individual chromosomes …

Chromosomes are exceedingly long topologically constrained polymers compacted in a cell
nucleus. We recently suggested that chromosomes are organized into loops by an active …

The immunoglobulin heavy-chain (Igh) locus is organized into distinct regions that contain
multiple variable (VH), diversity (DH), joining (JH) and constant (CH) coding elements. How …

Genome function in higher eukaryotes involves major changes in the spatial organization of
the chromatin fiber. Nevertheless, our understanding of chromatin folding is remarkably …

Chromatin folding inside the interphase nucleus of eukaryotic cells is done on multiple
scales of length and time. Despite recent progress in understanding the folding motifs of …

How long thread-like eukaryotic chromosomes fit tidily in the small volume of the nucleus
without significant entanglement is just beginning to be understood, thanks to major …