Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

The activation of the N-methyl D-aspartate receptor (NMDAR) is controlled by a glutamate-
binding site and a distinct, independently regulated, co-agonist-binding site. In most brain …

Several attempts have been made to enhance N-methyl-D-aspartate (NMDA) receptor
function in schizophrenia, but they have yielded mixed results. Luvadaxistat, a D-amino acid …

Many risk genes interact synergistically to produce schizophrenia and many
neurotransmitter interactions have been implicated. We have developed a circuit-based …

1. After 50 years of antipsychotic drug development focused on the dopamine D2 receptor,
schizophrenia remains a chronic, disabling disorder for most affected individuals. 2. Studies …

BACKGROUND: Glutamate has been thought to have a role in mental disorders. Because
the postmortem interval (PMI) has such a pronounced effect on glutamate and other amino …

Schizophrenia is a severe mental disorder associated with a characteristic constellation of
symptoms and neurocognitive deficits. At present, etiological mechanisms remain relatively …