Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals

V Lažetić, LE Batachari, AB Russell, ER Troemel - Bioessays, 2023 - Wiley Online Library
Although the type‐I interferon (IFN‐I) response is considered vertebrate‐specific, recent
findings about the Intracellular Pathogen Response (IPR) in nematode Caenorhabditis …

Understanding the factors regulating host–microbiome interactions using Caenorhabditis elegans

A Singh, RJ Luallen - Philosophical Transactions of the …, 2024 - royalsocietypublishing.org
The Human Microbiome Project was a research programme that successfully identified
associations between microbial species and healthy or diseased individuals. However, a …

Bacterial c-di-GMP has a key role in establishing host–microbe symbiosis

N Obeng, A Czerwinski, D Schütz, J Michels… - Nature …, 2023 - nature.com
Most microbes evolve faster than their hosts and should therefore drive evolution of host–
microbe interactions. However, relatively little is known about the characteristics that define …

Host and microbiome jointly contribute to environmental adaptation

C Petersen, IK Hamerich, KL Adair… - The ISME …, 2023 - academic.oup.com
Most animals and plants have associated microorganisms, collectively referred to as their
microbiomes, which can provide essential functions. Given their importance, host-associated …

The Caenorhabditis elegans proteome response to two protective Pseudomonas symbionts

B Pees, L Peters, C Treitz, IK Hamerich, KAB Kissoyan… - Mbio, 2024 - journals.asm.org
The Caenorhabditis elegans natural microbiota isolates Pseudomonas lurida MYb11 and
Pseudomonas fluorescens MYb115 protect the host against pathogens through distinct …

A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance

T Sengupta, J St. Ange, R Kaletsky, RS Moore… - PLoS …, 2024 - journals.plos.org
C. elegans can learn to avoid pathogenic bacteria through several mechanisms, including
bacterial small RNA-induced learned avoidance behavior, which can be inherited …

Bacteria are a major determinant of Orsay virus transmission and infection in Caenorhabditis elegans

BG Vassallo, N Scheidel, SEJ Fischer, DH Kim - Elife, 2024 - elifesciences.org
The microbiota is a key determinant of the physiology and immunity of animal hosts. The
factors governing the transmissibility of viruses between susceptible hosts are incompletely …

Distinct members of the Caenorhabditis elegans CeMbio reference microbiota exert cryptic virulence that is masked by host defense

X Gonzalez, JE Irazoqui - Molecular Microbiology, 2024 - Wiley Online Library
Microbiotas are complex microbial communities that colonize specific niches in the host and
provide essential organismal functions that are important in health and disease …

Thousands of Pristionchus pacificus orphan genes were integrated into developmental networks that respond to diverse environmental microbiota

M Athanasouli, N Akduman, W Röseler, P Theam… - PLoS …, 2023 - journals.plos.org
Adaptation of organisms to environmental change may be facilitated by the creation of new
genes. New genes without homologs in other lineages are known as taxonomically …

Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection

NB Haghani, RH Lampe, BS Samuel… - Microbiology …, 2024 - journals.asm.org
In the wild, C. elegans are emersed in environments teeming with a veritable menagerie of
microorganisms. The C. elegans cuticular surface serves as a barrier and first point of …