▪ Abstract Depression is a disorder of the representation and regulation of mood and
emotion. The circuitry underlying the representation and regulation of normal emotion and …

As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

Individual differences in affective and social processes may arise from variability in
amygdala-medial prefrontal (mPFC) circuitry and related genetic heterogeneity. To explore …

Mood disorders may be associated with global and regional changes in cerebral blood flow
and metabolism. The accumulated functional neuroimaging findings in mood disorders were …

Background: Functional brain imaging studies in unipolar and secondary depression have
generally found decreased prefrontal cortical activity, but in bipolar disorders findings have …

OBJECTIVE: The purpose of this study was to determine whether microstructural
abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late …

The onset and reversibility of major depression is likely to be explained by diffuse
neuromodulatory mechanisms rather than permanent abnormalities of connectivity and …

Strategies for treating Alzheimer's disease (AD) include therapies designed to decrease
senile plaque (SP) formation and/or promote clearance of SPs, but clinical trials of these …

We conducted a quantitative review of the imaging literature using meta-analytic
methodology to characterize further the magnitude of hippocampal deficit in probable …

Subcallosal area 25 is one of the least understood regions of the anterior cingulate cortex,
but activity in this area is emerging as a crucial correlate of mood and affective disorder …