Glutathione (γ-l-glutamyl-l-cysteinylglycine) is a small tripeptide found at millimolar
concentrations in nearly all eukaryotes as well as many prokaryotic cells. Glutathione …

There is a growing appreciation that reductive stress represents a disturbance in the redox
state that is harmful to biological systems. On a cellular level, the presence of increased …

Oxidative stress contributes to the pathogenesis of acute lung injury. Protein S-
glutathionylation plays an important role in cellular antioxidant defense. Here we report that …

Rationale: Diabetes mellitus is a complex, multisystem disease, affecting large populations
worldwide. Chronic CaMKII (Ca2+/calmodulin-dependent kinase II) activation may occur in …

Redox signaling and cardiac function are tightly linked. However, it is largely unknown
which protein targets are affected by hydrogen peroxide (H2O2) in cardiomyocytes that …

Global epidemiological studies show that chronic non-communicable diseases such as
atherosclerosis and metabolic disorders represent the leading cause of premature mortality …

Insulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …

Thiol-based redox compounds, namely thioredoxins (Trxs), glutaredoxins (Grxs) and
peroxiredoxins (Prxs), stand as a pivotal group of proteins involved in antioxidant processes …

Abstract Purpose of Review In highly prevalent cardiac diseases, new therapeutic
approaches are needed. Since the first description of oxidative stress in heart failure …

Redox reactions play a key role in maintaining essential biological processes. Deviations in
redox pathways result in the development of various pathologies at cellular and organismal …