Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis

M Buchynskyi, V Oksenych, I Kamyshna, SG Vari… - Viruses, 2023 - mdpi.com
Metabolic-associated fatty liver disease (MAFLD) and its potential impact on the severity of
COVID-19 have gained significant attention during the pandemic. This review aimed to …

Metformin therapy changes gut microbiota alpha-diversity in COVID-19 patients with type 2 diabetes: the role of SARS-CoV-2 variants and antibiotic treatment

P Petakh, I Kamyshna, V Oksenych, D Kainov… - Pharmaceuticals, 2023 - mdpi.com
The gut microbiota play a crucial role in maintaining host health and have a significant
impact on human health and disease. In this study, we investigated the alpha diversity of gut …

Exploring Paxlovid Efficacy in COVID-19 Patients with MAFLD: Insights from a Single-Center Prospective Cohort Study

M Buchynskyi, V Oksenych, I Kamyshna, O Kamyshnyi - Viruses, 2024 - mdpi.com
This study investigates the intricate interplay between Metabolic-associated Fatty Liver
Disease (MAFLD) and COVID-19, exploring the impact of MAFLD on disease severity …

The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism

K Kozak, H Pavlyshyn, O Kamyshnyi, O Shevchuk… - Viruses, 2023 - mdpi.com
Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging
problems today. COVID-19 in children could be asymptomatic, but can result in a fatal …

From bench to bedside: potential of translational research in COVID-19 and beyond

N Shukla, U Shamim, P Agarwal… - Briefings in …, 2024 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus
disease 2019 (COVID-19) have been around for more than 3 years now. However, due to …

Genomic insight into COVID-19 severity in MAFLD patients: a single-center prospective cohort study

M Buchynskyi, V Oksenych, I Kamyshna… - Frontiers in …, 2024 - frontiersin.org
This study investigated the influence of single nucleotide polymorphisms (SNPs) in genes
associated with the interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 …

Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes

M Buchynskyi, V Oksenych, I Kamyshna, I Vorobets… - Viruses, 2024 - mdpi.com
Metabolic-associated fatty liver disease (MAFLD) is a risk factor for severe COVID-19. This
study explores the potential influence of gut hormone receptor and immune response gene …

Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response

Y Wang, P Li, L Xu, AC de Vries, RJ Rottier, W Wang… - Iscience, 2023 - cell.com
Severe infections with coronaviruses are often accompanied with hyperinflammation,
requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By …

[HTML][HTML] Metformin in Antiviral Therapy: Evidence and Perspectives

I Halabitska, P Petakh, O Lushchak, I Kamyshna… - …, 2024 - pmc.ncbi.nlm.nih.gov
Metformin, a widely used antidiabetic medication, has emerged as a promising broad-
spectrum antiviral agent due to its ability to modulate cellular pathways essential for viral …

Precision medicine for pandemics: stratification of COVID-19 molecular phenotypes defined by topological analysis of global blood gene expression.

R Penrice-Randal, F Strazzeri, B Ernst, B Van Eeckhout… - medRxiv, 2024 - medrxiv.org
Precision medicine offers a promising avenue for better therapeutic responses to pandemics
such as COVID-19. This study leverages independent patient cohorts in Florence and Liège …