Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due
to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK …

The RET receptor tyrosine kinase is crucial for normal development but also contributes to
pathologies that reflect both the loss and the gain of RET function. Activation of RET occurs …

Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …

Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction
pathways mediating development and multicellular communication in metazoans. Their …

A typical protein kinase must recognize between one and a few hundred bona fide
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …

The inadvertent activation of the Abelson tyrosine kinase (Abl) causes chronic myelogenous
leukemia (CML). A small-molecule inhibitor of Abl (STI-571) is effective in the treatment of …

▪ Abstract Tyrosine phosphorylation is one of the key covalent modifications that occurs in
multicellular organisms as a result of intercellular communication during embryogenesis and …

The Escherichia coli biotin holoenzyme synthetase, BirA, catalyzes transfer of biotin to the
epsilon amino group of a specific lysine residue of the biotin carboxyl carrier protein (BCCP) …

Communication between cells assumes particular importance in multicellular organisms.
The growth, migration and differentiation of cells in the embryo, and their organization into …

Src is the best understood member of a family of 9 tyrosine kinases that regulates cellular
responses to extracellular stimuli. Activated mutants of Src are oncogenic. Using Src as an …