Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

The histone acetyltransferases (HATs) of the MYST family are highly conserved in
eukaryotes and carry out a significant proportion of all nuclear acetylation. These enzymes …

The role of the androgen receptor (AR) in estrogen receptor (ER)-α-positive breast cancer is
controversial, constraining implementation of AR-directed therapies. Using a diverse …

The molecular classification for breast carcinomas has been used in clinical studies with a
simple surrogate panel of immunohistochemistry (IHC) markers. The objective of this current …

BACKGROUND Circulating tumor cells (CTCs) are associated with prognosis in a variety of
human cancers and have been proposed as a liquid biopsy for follow-up examinations. We …

Rationale: Claudin (CLDN)-1, a key component of tight junction complexes, was down-
regulated in human lung adenocarcinomas. Objectives: To investigate the clinical …

Breast cancer is the most common type of cancer among women worldwide, and metastasis
represents the most devastating stage of the disease. Recent studies have revealed that …

The actin-bundling protein, fascin, is a member of the cytoskeletal protein family that has
restricted expression in specialized normal cells. However, many studies have reported the …

The majority of patients with lung cancer present with metastatic disease. Chronic
inflammation and subsequent activation of nuclear factor-κB (NF-κB) have been associated …

Background: Breast-cancer metastasis suppressor 1 (BRMS1) gene encodes for a
predominantly nuclear protein that differentially regulates the expression of multiple genes …