Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Chronic pain affects a large part of the population causing functional disability, being often
associated with coexisting psychological disorders, such as depression and anxiety …

Chronic pain is one of the most prevalent health problems in our modern world, with millions
of people debilitated by conditions such as back pain, headache and arthritis. To address …

Chronic pain conditions are associated with abnormalities in brain structure and function.
Moreover, some studies indicate that brain activity related to the subjective perception of …

Pain and stress share significant conceptual and physiological overlaps. Both phenomena
challenge the body's homeostasis and necessitate decision-making to help animals adapt to …

It has been argued that emotion, pain and cognitive control are functionally segregated in
distinct subdivisions of the cingulate cortex. However, recent observations encourage a …

As humans, we perceive feelings from our bodies that relate our state of well-being, our
energy and stress levels, our mood and disposition. How do we have these feelings? What …

While chronic pain is considered by some to be a CNS disease, little is understood about
underlying neurobiological mechanisms. Addiction models have heuristic value in this …

Stress is a well‐known risk factor in the development of addiction and in addiction relapse
vulnerability. A series of population‐based and epidemiological studies have identified …

CONTEXT: The perception of pain due to an acute injury or in clinical pain states undergoes
substantial processing at supraspinal levels. Supraspinal, brain mechanisms are …