Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review
Traditionally, selected plant sources have been explored for medicines to treat convulsions.
This continues today, especially in countries with low-income rates and poor medical …
This continues today, especially in countries with low-income rates and poor medical …
Toward the use of novel alternative methods in epilepsy modeling and drug discovery
C Miguel Sanz, M Martinez Navarro… - Frontiers in …, 2023 - frontiersin.org
Epilepsy is a chronic brain disease and, considering the amount of people affected of all
ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure …
ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure …
Imaging approaches to investigate pathophysiological mechanisms of brain disease in zebrafish
Zebrafish has become an essential model organism in modern biomedical research. Owing
to its distinctive features and high grade of genomic homology with humans, it is increasingly …
to its distinctive features and high grade of genomic homology with humans, it is increasingly …
[HTML][HTML] Classification of current experimental models of epilepsy
Introduction: This article provides an overview of several experimental models, including in
vivo, genetics, chemical, knock-in, knock-out, electrical, in vitro, and optogenetics models …
vivo, genetics, chemical, knock-in, knock-out, electrical, in vitro, and optogenetics models …
[HTML][HTML] Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review
D Camussi, M Marchese, F Nicoletti, FM Santorelli… - Cells, 2025 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits
in social skills and the presence of repetitive and restricted behaviors and interests. The …
in social skills and the presence of repetitive and restricted behaviors and interests. The …
CircRNA‐associated ceRNA regulatory networks as emerging mechanisms governing the development and biophysiopathology of epilepsy
M Kohansal, YK Alghanimi, SR Banoon… - CNS Neuroscience …, 2024 - Wiley Online Library
The etiology of epilepsy is ascribed to the synchronized aberrant neuronal activity within the
brain. Circular RNAs (circRNAs), a class of non‐coding RNAs characterized by their circular …
brain. Circular RNAs (circRNAs), a class of non‐coding RNAs characterized by their circular …
Berberine and hesperidin prevent the memory consolidation impairment induced by pentylenetetrazole in zebrafish
This study verified the effects of the natural compounds berberine and hesperidin on seizure
development and cognitive impairment triggered by pentylenetetrazole (PTZ) in zebrafish …
development and cognitive impairment triggered by pentylenetetrazole (PTZ) in zebrafish …
[HTML][HTML] Anti-Epileptic Activity of Mitocurcumin in a Zebrafish–Pentylenetetrazole (PTZ) Epilepsy Model
Background/Objectives: Ongoing challenges in epilepsy therapy warrant research on
alternative treatments that offer improved efficacy and reduced side effects. Designed to …
alternative treatments that offer improved efficacy and reduced side effects. Designed to …
Development and applications of a machine learning model for an in-depth analysis of pentylenetetrazol-induced seizure-like behaviors in adult zebrafish
BD Fontana, L Blanco, AE Uchoa, ML Müller… - …, 2025 - ibroneuroscience.org
Epilepsy, a neurological disorder causing recurring seizures, is often studied in zebrafish by
exposing animals to pentylenetetrazol (PTZ), which induces clonic-and tonic-like behaviors …
exposing animals to pentylenetetrazol (PTZ), which induces clonic-and tonic-like behaviors …
Reconnoitring antiepileptic and anxiolytic effects of Indian herbs: Findings from zebrafish behavioral research
S Bhattacharya, D Chatterjee, R Goswami, B Pal… - Pharmacological …, 2024 - Elsevier
Introduction In the 21st century, neuropsychological disorders such as anxiety, insomnia,
and epilepsy have become increasingly prevalent due to irregular lifestyles, unhealthy food …
and epilepsy have become increasingly prevalent due to irregular lifestyles, unhealthy food …