Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review

B Knap, D Nieoczym, U Kundap… - Frontiers in Molecular …, 2023 - frontiersin.org
Traditionally, selected plant sources have been explored for medicines to treat convulsions.
This continues today, especially in countries with low-income rates and poor medical …

Toward the use of novel alternative methods in epilepsy modeling and drug discovery

C Miguel Sanz, M Martinez Navarro… - Frontiers in …, 2023 - frontiersin.org
Epilepsy is a chronic brain disease and, considering the amount of people affected of all
ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure …

Imaging approaches to investigate pathophysiological mechanisms of brain disease in zebrafish

L Turrini, L Roschi, G de Vito, FS Pavone… - International Journal of …, 2023 - mdpi.com
Zebrafish has become an essential model organism in modern biomedical research. Owing
to its distinctive features and high grade of genomic homology with humans, it is increasingly …

[HTML][HTML] Classification of current experimental models of epilepsy

C Rubio, H Romo-Parra, A López-Landa… - Brain Sciences, 2024 - mdpi.com
Introduction: This article provides an overview of several experimental models, including in
vivo, genetics, chemical, knock-in, knock-out, electrical, in vitro, and optogenetics models …

[HTML][HTML] Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review

D Camussi, M Marchese, F Nicoletti, FM Santorelli… - Cells, 2025 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits
in social skills and the presence of repetitive and restricted behaviors and interests. The …

CircRNA‐associated ceRNA regulatory networks as emerging mechanisms governing the development and biophysiopathology of epilepsy

M Kohansal, YK Alghanimi, SR Banoon… - CNS Neuroscience …, 2024 - Wiley Online Library
The etiology of epilepsy is ascribed to the synchronized aberrant neuronal activity within the
brain. Circular RNAs (circRNAs), a class of non‐coding RNAs characterized by their circular …

Berberine and hesperidin prevent the memory consolidation impairment induced by pentylenetetrazole in zebrafish

KT Bertoncello, G Rodrigues, CD Bonan - Behavioural Brain Research, 2024 - Elsevier
This study verified the effects of the natural compounds berberine and hesperidin on seizure
development and cognitive impairment triggered by pentylenetetrazole (PTZ) in zebrafish …

[HTML][HTML] Anti-Epileptic Activity of Mitocurcumin in a Zebrafish–Pentylenetetrazole (PTZ) Epilepsy Model

AD Ciubotaru, CE Leferman, BE Ignat, A Knieling… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: Ongoing challenges in epilepsy therapy warrant research on
alternative treatments that offer improved efficacy and reduced side effects. Designed to …

Development and applications of a machine learning model for an in-depth analysis of pentylenetetrazol-induced seizure-like behaviors in adult zebrafish

BD Fontana, L Blanco, AE Uchoa, ML Müller… - …, 2025 - ibroneuroscience.org
Epilepsy, a neurological disorder causing recurring seizures, is often studied in zebrafish by
exposing animals to pentylenetetrazol (PTZ), which induces clonic-and tonic-like behaviors …

Reconnoitring antiepileptic and anxiolytic effects of Indian herbs: Findings from zebrafish behavioral research

S Bhattacharya, D Chatterjee, R Goswami, B Pal… - Pharmacological …, 2024 - Elsevier
Introduction In the 21st century, neuropsychological disorders such as anxiety, insomnia,
and epilepsy have become increasingly prevalent due to irregular lifestyles, unhealthy food …