The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

Mitochondrial control of cell death | Nature Medicine Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Introduction Increasing evidence suggests a role for the gut microbiome in central nervous
system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids …

Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were
outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild …

This review addresses recent advances in specific mechanisms of hepatotoxicity. Because
of its unique metabolism and relationship to the gastrointestinal tract, the liver is an important …

Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various
host processes. Similarly, there is growing attention on members of the microbiota that are …

Cholestasis is an impairment of bile formation/flow at the level of the hepatocyte and/or
cholangiocyte. The first, and for the moment, most established medical treatment is the …

Bile acids, the water-soluble, amphipathic end products of cholesterol metabolism, are
involved in liver, biliary, and intestinal disease. Formed in the liver, bile acids are absorbed …

Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made
towards elucidating the mechanisms controlling the major regulatory pathways are now …

Several studies have characterized the cellular and molecular mechanisms of hepatocyte
injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs …