Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Diagnosis and management of chronic neuropathic pain are challenging, leading to current
efforts to characterize 'objective'biomarkers of pain using imaging or neurophysiological …

Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …

Background Grip strength is a widely used and well-validated measure of overall health that
is increasingly understood to index risk for psychiatric illness and neurodegeneration in …

Reliable and objective biomarkers promise to improve the assessment and treatment of
chronic pain. Resting-state electroencephalography (EEG) is broadly available, easy to use …

Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent
level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool …

Rumination is a cognitive style characterized by repetitive thoughts about one's negative
internal states and is a common symptom of depression. Previous studies have linked trait …

Characterizing cerebral contributions to individual variability in pain processing is crucial for
personalized pain medicine, but has yet to be done. In the present study, we address this …

Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …

Sleep health is both conceptually and operationally a composite concept containing multiple
domains of sleep. In line with this, high dependence and interaction across different …