The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Mitochondria empower the liver to regulate lipid homeostasis by enabling fatty acid
oxidation during starvation and lipogenesis during nutrient-rich conditions. It is unknown if …

De novo lipogenesis (DNL) is a complex and highly regulated process in which
carbohydrates from circulation are converted into fatty acids that are then used for …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Cold-induced thermogenesis (CIT) is widely studied as a potential avenue to treat obesity,
but a thorough understanding of the metabolic changes driving CIT is lacking. Here, we …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

The isolation and biochemical characterization of lipid droplet (LD)-associated mitochondria
revealed the capacity of the cell to produce and maintain distinct mitochondrial populations …