Anticancer potential of lichens' secondary metabolites

Z Solárová, A Liskova, M Samec, P Kubatka… - Biomolecules, 2020 - mdpi.com
Lichens produce different classes of phenolic compounds, including anthraquinones,
xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed …

Bioactive lichen secondary metabolites and their presence in species from Chile

E Poulsen-Silva, F Gordillo-Fuenzalida, C Atala… - Metabolites, 2023 - mdpi.com
Lichens are symbiotic organisms composed of at least one fungal and one algal species.
They are found in different environments around the world, even in the poles and deserts …

Inhibition of thioredoxin reductase 1 by vulpinic acid suppresses the proliferation and migration of human breast carcinoma

ŞN Kalın, A Altay, H Budak - Life Sciences, 2022 - Elsevier
Aims It was aimed to investigate the thioredoxin reductase 1 (TrxR1)-targeted anticancer
effect of vulpinic (VA) and lecanoric (LA) acids, which are lichen secondary metabolites, on …

Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution

A Torres-Benítez, JE Ortega-Valencia… - Frontiers in …, 2023 - frontiersin.org
The objective of this research was to characterize the chemical composition of ethanolic
extracts of the lichen species Placopsis contortuplicata, Ochrolechia frigida, and Umbilicaria …

Biological effects of gyrophoric acid and other lichen derived metabolites, on cell proliferation, apoptosis and cell signaling pathways

M Mohammadi, L Bagheri, A Badreldin, P Fatehi… - Chemico-biological …, 2022 - Elsevier
Secondary metabolites from fungi, algae and lichens have remarkable biological activities
as antibiotics, fungicides, antiviral drugs, and cancer therapeutics. This review focuses on …

Ribosome-directed therapies in cancer

G Temaj, S Chichiarelli, M Eufemi, F Altieri… - Biomedicines, 2022 - mdpi.com
The human ribosomes are the cellular machines that participate in protein synthesis, which
is deeply affected during cancer transformation by different oncoproteins and is shown to …

Inhibiting eukaryotic ribosome biogenesis

D Awad, M Prattes, L Kofler, I Rössler, M Loibl, M Pertl… - BMC biology, 2019 - Springer
Background Ribosome biogenesis is a central process in every growing cell. In eukaryotes,
it requires more than 250 non-ribosomal assembly factors, most of which are essential …

A review of twenty years of research on the regulation of signaling pathways by natural products in breast cancer

M Naeem, MO Iqbal, H Khan, MM Ahmed, M Farooq… - Molecules, 2022 - mdpi.com
Breast cancer (BC) is the second leading cause of death among women, and it has become
a global health issue due to the increasing number of cases. Different treatment options …

Lichens as a repository of bioactive compounds: an open window for green therapy against diverse cancers

TUH Dar, SA Dar, SU Islam, ZA Mangral, R Dar… - Seminars in Cancer …, 2022 - Elsevier
Lichens, algae and fungi-based symbiotic associations, are sources of many important
secondary metabolites, such as antibiotics, anti-inflammatory, antioxidants, and anticancer …

A review of anti-cancer and related properties of lichen-extracts and metabolites

AH Tripathi, N Negi, R Gahtori, A Kumari… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Background: Lichens are a composite consortium of a fungus and an alga. The symbiotic
organisms are naturally equipped with distinct characteristics as compared to constituting …