Transcriptional regulatory network of high-value active ingredients in medicinal plants

H Zheng, X Fu, J Shao, Y Tang, M Yu, L Li… - Trends in Plant …, 2023 - cell.com
High-value active ingredients in medicinal plants have attracted research attention because
of their benefits for human health, such as the antimalarial artemisinin, anticardiovascular …

Chemical elicitors versus secondary metabolite production in vitro using plant cell, tissue and organ cultures: recent trends and a sky eye view appraisal

CC Giri, M Zaheer - Plant Cell, Tissue and Organ Culture (PCTOC), 2016 - Springer
Plant secondary biosynthetic pathways are exceedingly inducible by elicitors and facilitate
enhanced metabolite production using plant cell tissue and organ cultures. Elicitors can …

The Transcription Factor CrWRKY1 Positively Regulates the Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

N Suttipanta, S Pattanaik, M Kulshrestha… - Plant …, 2011 - academic.oup.com
Catharanthus roseus produces a large array of terpenoid indole alkaloids (TIAs) that are an
important source of natural or semisynthetic anticancer drugs. The biosynthesis of TIAs is …

Making small molecules in plants: a chassis for synthetic biology‐based production of plant natural products

X Liu, P Zhang, Q Zhao… - Journal of Integrative Plant …, 2023 - Wiley Online Library
Plant natural products have been extensively exploited in food, medicine, flavor, cosmetic,
renewable fuel, and other industrial sectors. Synthetic biology has recently emerged as a …

A differentially regulated AP 2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in …

P Paul, SK Singh, B Patra, X Sui, S Pattanaik… - New …, 2017 - Wiley Online Library
Catharanthus roseus produces bioactive terpenoid indole alkaloids (TIA s), including the
chemotherapeutics, vincristine and vinblastine. Transcriptional regulation of TIA …

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

A Van Moerkercke, P Steensma, F Schweizer… - Proceedings of the …, 2015 - pnas.org
Plants make specialized bioactive metabolites to defend themselves against attackers. The
conserved control mechanisms are based on transcriptional activation of the respective …

Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures

G Kai, H Xu, C Zhou, P Liao, J **ao, X Luo, L You… - Metabolic …, 2011 - Elsevier
Tanshinone is a group of active diterpenes widely used in treatment of cardiovascular
diseases. Here, we report the introduction of genes encoding 3-hydroxy-3-methylglutaryl …

Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolites

Q Pan, NR Mustafa, K Tang, YH Choi… - Phytochemistry reviews, 2016 - Springer
As the only source for the low-abundance antitumor agents vinblastine and vincristine,
Catharanthus roseus is highly valued and has been studied extensively as a model for …

[HTML][HTML] Root cultures, a boon for the production of valuable compounds: A comparative review

MJ Hussain, Y Abbas, N Nazli, S Fatima, S Drouet… - Plants, 2022 - mdpi.com
Medicinal plants are an inevitable source of pharmaceutical drugs and most of the world
population depends on these plants for health benefits. The increasing global demand for …

Genetically transformed roots: from plant disease to biotechnological resource

MI Georgiev, E Agostini, J Ludwig-Müller, J Xu - Trends in biotechnology, 2012 - cell.com
Hairy root syndrome is a disease that is induced by Agrobacterium rhizogenes infection and
characterized by a proliferation of excessively branching roots. However, in the past 30 …