Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A **e, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy

KP De Sousa, I Rossi, M Abdullahi… - Wiley …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer
nanoparticles secreted by most cells. EVs are regarded as important mediators of …

Recent microfluidic advances in submicron to nanoparticle manipulation and separation

S Hettiarachchi, H Cha, L Ouyang, A Mudugamuwa… - Lab on a Chip, 2023 - pubs.rsc.org
Manipulation and separation of submicron and nanoparticles are indispensable in many
chemical, biological, medical, and environmental applications. Conventional technologies …

Recent progress in the effect of magnetic iron oxide nanoparticles on cells and extracellular vesicles

Y Chen, S Hou - Cell Death Discovery, 2023 - nature.com
At present, iron oxide nanoparticles (IONPs) are widely used in the biomedical field. They
have unique advantages in targeted drug delivery, imaging and disease treatment …

Cascaded microfluidic circuits for pulsatile filtration of extracellular vesicles from whole blood for early cancer diagnosis

Z Li, C Liu, Y Cheng, Y Li, J Deng, L Bai, L Qin… - Science …, 2023 - science.org
Tumor-derived extracellular vesicles (EVs) hold the potential to substantially improve
noninvasive early diagnosis of cancer. However, analysis of nanosized EVs in blood …

Platelet-derived drug delivery systems: pioneering treatment for cancer, cardiovascular diseases, infectious diseases, and beyond

Y Zhu, L Xu, Y Kang, Q Cheng, Y He, X Ji - Biomaterials, 2024 - Elsevier
Platelets play a critical role as circulating cells in the human body and contribute to essential
physiological processes such as blood clotting, hemostasis, vascular repair, and thrombus …

Advancements in extracellular vesicle targeted therapies for rheumatoid arthritis: insights into cellular origins, current perspectives, and emerging challenges

MT Jouybari, F Mojtahedi, M Babaahmadi… - Stem Cell Research & …, 2024 - Springer
Rheumatoid arthritis (RA) remains a challenging chronic autoimmune disorder
characterized by persistent joint inflammation and damage. While modern regenerative …

Platelets and platelet extracellular vesicles in drug delivery therapy: A review of the current status and future prospects

Z Dai, T Zhao, N Song, K Pan, Y Yang, X Zhu… - Frontiers in …, 2022 - frontiersin.org
Platelets are blood cells that are primarily produced by the shedding of megakaryocytes in
the bone marrow. Platelets participate in a variety of physiological and pathological …

High Throughput and Noninvasive Exosomal PD-L1 Detection for Accurate Immunotherapy Response Prediction via Tim4-Functionalized Magnetic Core–Shell Metal …

H Wang, Y Liu, L Zhang, X Li, G Zhao, Z Song… - Analytical …, 2023 - ACS Publications
Exosomal PD-L1 has been increasingly considered a noninvasive and accurate predictive
marker for immunotherapy treatment response. However, the clinical monitoring of exosomal …

Progress in Isolation and Molecular Profiling of Small Extracellular Vesicles via Bead-Assisted Platforms

D Kozhevnikova, V Chernyshev, A Yashchenok - Biosensors, 2023 - mdpi.com
Tremendous interest in research of small extracellular vesicles (sEVs) is driven by the
participation of vesicles in a number of biological processes in the human body. Being …