Stimuli-responsive polymer-based nanosystems for cancer theranostics

D Wei, Y Sun, H Zhu, Q Fu - ACS nano, 2023‏ - ACS Publications
Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen
species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external …

Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

B Ji, M Wei, B Yang - Theranostics, 2022‏ - pmc.ncbi.nlm.nih.gov
Cancer immunotherapy has made tremendous clinical progress in advanced-stage
malignancies. However, patients with various tumors exhibit a low response rate to …

Synergistic reinforcing of immunogenic cell death and transforming tumor‐associated macrophages via a multifunctional cascade bioreactor for optimizing cancer …

C Huang, B Lin, C Chen, H Wang, X Lin… - Advanced …, 2022‏ - Wiley Online Library
Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct
a tumor microenvironment and activate antitumor immunity. This study proposes a two‐way …

Bioengineered nanogels for cancer immunotherapy

X Ma, SJ Li, Y Liu, T Zhang, P Xue, Y Kang… - Chemical Society …, 2022‏ - pubs.rsc.org
Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …

Leveraging semiconducting polymer nanoparticles for combination cancer immunotherapy

J Wu, K Pu - Advanced Materials, 2024‏ - Wiley Online Library
Cancer immunotherapy has become a promising method for cancer treatment, bringing
hope to advanced cancer patients. However, immune‐related adverse events caused by …

Fe/Mn bimetal-doped ZIF-8-coated luminescent nanoparticles with up/downconversion dual-mode emission for tumor self-enhanced NIR-II imaging and catalytic …

C Li, J Ye, X Yang, S Liu, Z Zhang, J Wang, K Zhang… - ACS …, 2022‏ - ACS Publications
ZIF-8, as an important photoresponsive metal–organic framework (MOF), holds great
promise in the field of cancer theranostics owing to its versatile physiochemical properties …

ER-targeting cyanine dye as an NIR photoinducer to efficiently trigger photoimmunogenic cancer cell death

H Ma, Y Lu, Z Huang, S Long, J Cao… - Journal of the …, 2022‏ - ACS Publications
Endoplasmic reticulum (ER) stress, caused by overproduction of reactive oxygen species
(ROS), has been shown to be responsible for immunogenic cell death (ICD). Seeking ROS …

Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

X Wu, Y Li, M Wen, Y **e, K Zeng, YN Liu… - Chemical Society …, 2024‏ - pubs.rsc.org
Immunotherapy harnesses the inherent immune system in the body to generate systemic
antitumor immunity, offering a promising modality for defending against cancer. However …

[HTML][HTML] Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

X Shen, D Pan, Q Gong, Z Gu, K Luo - Bioactive Materials, 2024‏ - Elsevier
Effective tumor treatment depends on optimizing drug penetration and accumulation in
tumor tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key …

Activatable cancer sono‐immunotherapy using semiconducting polymer nanobodies

Z Zeng, C Zhang, S He, J Li, K Pu - Advanced Materials, 2022‏ - Wiley Online Library
Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its
clinical applications are hindered by the “always‐on” pharmacological activities of …