Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage
A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification
While N6‐methyladenosine (m6A) is a well‐known epigenetic modification in bacterial DNA,
it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential …
it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential …
Map** and elucidating the function of modified bases in DNA
Chemically modified bases exist naturally in genomic DNA. Research into these bases has
been invigorated by the discovery of several modified bases in the mammalian genome, in …
been invigorated by the discovery of several modified bases in the mammalian genome, in …
Knockout of protein phosphatase 1 in Leishmania major reveals its role during RNA polymerase II transcription termination
The genomes of kinetoplastids are organized into polycistronic transcription units that are
flanked by a modified DNA base (base J, beta-D-glucosyl-hydroxymethyluracil). Previous …
flanked by a modified DNA base (base J, beta-D-glucosyl-hydroxymethyluracil). Previous …
Sequencing abasic sites in DNA at single-nucleotide resolution
In DNA, the loss of a nucleobase by hydrolysis generates an abasic site. Formed as a result
of DNA damage, as well as a key intermediate during the base excision repair pathway …
of DNA damage, as well as a key intermediate during the base excision repair pathway …
TET methylcytosine oxidases: new insights from a decade of research
In mammals, DNA methyltransferases transfer a methyl group from S-adenosylmethionine to
the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has …
the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has …
Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine
Ten-eleven translocation (TET) enzymes catalyze stepwise oxidation of 5-methylcytosine
(mC) to yield 5-hydroxymethylcytosine (hmC) and the rarer bases 5-formylcytosine (fC) and …
(mC) to yield 5-hydroxymethylcytosine (hmC) and the rarer bases 5-formylcytosine (fC) and …
[HTML][HTML] CRISPR/Cas9 and glycomics tools for Toxoplasma glycobiology
E Gas-Pascual, HT Ichikawa, MO Sheikh… - Journal of Biological …, 2019 - Elsevier
Infection with the protozoan parasite Toxoplasma gondii is a major health risk owing to birth
defects, its chronic nature, ability to reactivate to cause blindness and encephalitis, and high …
defects, its chronic nature, ability to reactivate to cause blindness and encephalitis, and high …
Base J and H3.V Regulate Transcriptional Termination in Trypanosoma brucei
Trypanosoma brucei is a protozoan parasite that lacks many transcription factors found in
other eukaryotes, such as those whose binding demarcates enhancers. T. brucei retains …
other eukaryotes, such as those whose binding demarcates enhancers. T. brucei retains …
[HTML][HTML] Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes
DNA modifications add another layer of complexity to the eukaryotic genome to regulate
gene expression, playing critical roles as epigenetic marks. In eukaryotes, the study of DNA …
gene expression, playing critical roles as epigenetic marks. In eukaryotes, the study of DNA …