Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Microbial metabolites in the marine carbon cycle

MA Moran, EB Kujawinski, WF Schroer, SA Amin… - Nature …, 2022 - nature.com
One-quarter of photosynthesis-derived carbon on Earth rapidly cycles through a set of short-
lived seawater metabolites that are generated from the activities of marine phytoplankton …

Current status and applications of genome-scale metabolic models

C Gu, GB Kim, WJ Kim, HU Kim, SY Lee - Genome biology, 2019 - Springer
Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction
associations for entire metabolic genes in an organism, and can be simulated to predict …

Multi-omics approaches to disease

Y Hasin, M Seldin, A Lusis - Genome biology, 2017 - Springer
High-throughput technologies have revolutionized medical research. The advent of
genoty** arrays enabled large-scale genome-wide association studies and methods for …

A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism

H Lu, F Li, BJ Sánchez, Z Zhu, G Li, I Domenzain… - Nature …, 2019 - nature.com
Genome-scale metabolic models (GEMs) represent extensive knowledgebases that provide
a platform for model simulations and integrative analysis of omics data. This study …

Light-driven fine chemical production in yeast biohybrids

J Guo, M Suástegui, KK Sakimoto, VM Moody, G **ao… - Science, 2018 - science.org
Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile
chemical synthesis platforms by integrating the light-harvesting properties of semiconductors …

Rewriting yeast central carbon metabolism for industrial isoprenoid production

AL Meadows, KM Hawkins, Y Tsegaye, E Antipov… - Nature, 2016 - nature.com
A bio-based economy has the potential to provide sustainable substitutes for petroleum-
based products and new chemical building blocks for advanced materials. We previously …

Yeast systems biology: model organism and cell factory

J Nielsen - Biotechnology journal, 2019 - Wiley Online Library
For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a
cell factory for the production of bread, beer, and wine. In more recent years, this yeast has …

Microbial fuel cell (MFC) power performance improvement through enhanced microbial electrogenicity

M Li, M Zhou, X Tian, C Tan, CT McDaniel… - Biotechnology …, 2018 - Elsevier
Within the past 5 years, tremendous advances have been made to maximize the
performance of microbial fuel cells (MFCs) for both “clean” bioenergy production and …

A highly characterized yeast toolkit for modular, multipart assembly

ME Lee, WC DeLoache, B Cervantes… - ACS synthetic …, 2015 - ACS Publications
Saccharomyces cerevisiae is an increasingly attractive host for synthetic biology because of
its long history in industrial fermentations. However, until recently, most synthetic biology …