The long road toward COVID-19 herd immunity: vaccine platform technologies and mass immunization strategies

LSF Frederiksen, Y Zhang, C Foged… - Frontiers in …, 2020 - frontiersin.org
There is an urgent need for effective countermeasures against the current emergence and
accelerating expansion of coronavirus disease 2019 (COVID-19), caused by severe acute …

[HTML][HTML] Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases

JX Yang, JC Tseng, GY Yu, Y Luo, CYF Huang… - Pharmaceutics, 2022 - mdpi.com
Vaccines are powerful tools for controlling microbial infections and preventing epidemic
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

TY Kuo, MY Lin, RL Coffman, JD Campbell… - Scientific reports, 2020 - nature.com
The COVID-19 pandemic is a worldwide health emergency which calls for an
unprecedented race for vaccines and treatment. In develo** a COVID-19 vaccine, we …

Toward precision adjuvants: optimizing science and safety

E Nanishi, DJ Dowling, O Levy - Current opinion in pediatrics, 2020 - journals.lww.com
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TLR agonists as mediators of trained immunity: mechanistic insight and immunotherapeutic potential to combat infection

AM Owen, JB Fults, NK Patil, A Hernandez… - Frontiers in …, 2021 - frontiersin.org
Despite advances in critical care medicine, infection remains a significant problem that
continues to be complicated with the challenge of antibiotic resistance …

CpG-adjuvanted hepatitis B vaccine (HEPLISAV-B®) update

GH Lee, SG Lim - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction: HEPLISAV-B is a hepatitis B vaccine composed of rHBsAg mixed with a
synthetic oligonucleotide containing CpG motifs that stimulate innate immunity through …

Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis

C Gidengil, MB Goetz, S Newberry, M Maglione, O Hall… - Vaccine, 2021 - Elsevier
Background Understanding the safety of vaccines is critical to inform decisions about
vaccination. Our objective was to conduct a systematic review of the safety of vaccines …

Multi-omics for COVID-19: driving development of therapeutics and vaccines

M Guo, M **ong, J Peng, T Guan, H Su… - National Science …, 2023 - academic.oup.com
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has raised global concern for
public health and economy. The development of therapeutics and vaccines to combat this …

Adjuvant effect of toll-like receptor 9 activation on cancer immunotherapy using checkpoint blockade

YC Chuang, JC Tseng, LR Huang, CM Huang… - Frontiers in …, 2020 - frontiersin.org
Immunotherapy using checkpoint blockade has revolutionized cancer treatment, improving
patient survival and quality of life. Nevertheless, the clinical outcomes of such …

Efficacy and safety of hepatitis B vaccine: An umbrella review of meta-analyses

J Qiu, S Zhang, Y Feng, X Su, J Cai… - Expert Review of …, 2024 - Taylor & Francis
Background There is a lack of synthesis of literature to determine hepatitis B vaccine (HepB)
strategies for hepatitis B virus (HBV) supported by quality evidence. We aimed to explore the …