Historically, biological control utilizes predatory species and pathogenic microorganisms to
reduce the population of mosquitoes as disease vectors. This is particularly important for the …

Control of aedine mosquito vectors, either by mosquito population reduction or replacement
with refractory mosquitoes, may play an essential role in the fight against arboviral diseases …

Mosquitoes (Aedes aegypti) were genetically modified to exhibit impaired vector
competence for dengue type 2 viruses (DENV-2). We exploited the natural antiviral RNA …

With dengue virus (DENV) becoming endemic in tropical and subtropical regions worldwide,
there is a pressing global demand for effective strategies to control the mosquitoes that …

Genetic modification of the vectorial capacity of mosquito vectors of human disease requires
promoters capable of driving gene expression with appropriate tissue and stage specificity …

Genetically altering the disease vector status of insects using recombinant DNA
technologies is being considered as an alternative to eradication efforts. Manipulating the …

Abstract Background The RNA interference (RNAi) pathway acts as an innate antiviral
immune response in Aedes aegypti, modulating arbovirus infection of mosquitoes. Sindbis …

Dengue virus (DENV) is an arbovirus transmitted to humans by Aedes mosquitoes. In the
insect vector, the small interfering RNA (siRNA) pathway is an important antiviral mechanism …

Suppression or elimination of vector populations is a tried and tested method for reducing
vector-borne disease, and a key component of integrated control programs. Genetic …

Mosquito-borne arboviruses are responsible for recent dengue, chikungunya, and Zika
pandemics. The yellow-fever mosquito, Aedes aegypti, plays an important role in the …