Pre‐eclampsia and fetal growth restriction (FGR) continue to cause unacceptably high levels
of morbidity and mortality, despite significant pharmaceutical and technological advances in …

Since 2020, the highly contagious nature and various transmission routes of SARS-CoV-2
have rendered the pandemic interminable. Vertical transmission through the placenta and …

Background A dramatic increase in fetal situs inversus diagnoses by ultrasound in the
months following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surge …

ACE2 expression is altered in pregnancy disorders and ACE2 gene variants are associated
with several major pregnancy complications including small-for-gestational-age, fetal growth …

Preeclampsia is one of the most common disorders that poses threat to both mothers and
neonates and a major contributor to perinatal morbidity and mortality worldwide. Viral …

Highlights•Human pluripotent stem cells possess differentiation potency into trophoblast
lineage.•Naive human pluripotent stem cells differentiate into trophoblasts via …

Congenital infections are a leading preventable cause of pregnancy complications
impacting both mother and fetus. Although advancements have been made in …

Abstract SARS-CoV-2, the causative virus of COVID-19, increases the risk of pregnancy
complications including hypertensive disorders and placental inflammation. The spike …

Background Several observational studies demonstrated that pregnant individuals with
COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine …

The type-I interferon (IFN) response constitutes the major innate immune pathway against
viruses in mammals. Despite its critical importance for antiviral defence, this pathway is …