Ferroptosis: mechanisms and links with diseases

H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

[HTML][HTML] Ferroptosis as a novel therapeutic target for cardiovascular disease

X Wu, Y Li, S Zhang, X Zhou - Theranostics, 2021 - ncbi.nlm.nih.gov
Cell death is an important component of the pathophysiology of cardiovascular disease. An
understanding of how cardiomyocytes die, and why regeneration of cells in the heart is …

[HTML][HTML] Molecular mechanisms of ferroptosis and their involvement in brain diseases

I Costa, DJ Barbosa, S Benfeito, V Silva… - Pharmacology & …, 2023 - Elsevier
Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

P Liu, Y Feng, H Li, X Chen, G Wang, S Xu, Y Li… - Cellular & molecular …, 2020 - Springer
Background Ferroptosis is a newly recognized type of cell death, which is different from
traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis …

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

AA Kapralov, Q Yang, HH Dar, YY Tyurina… - Nature chemical …, 2020 - nature.com
Ferroptotic death is the penalty for losing control over three processes—iron metabolism,
lipid peroxidation and thiol regulation—that are common in the pro-inflammatory …

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Q Ru, Y Li, L Chen, Y Wu, J Min, F Wang - Signal transduction and …, 2024 - nature.com
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury

F Lin, W Chen, J Zhou, J Zhu, Q Yao, B Feng… - Cell death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) have attracted interest for their potential to alleviate liver
injury. Here, the protective effect of MSCs on carbon tetrachloride (CCl4)-induced acute liver …

The application of ferroptosis in diseases

Y Qiu, Y Cao, W Cao, Y Jia, N Lu - Pharmacological Research, 2020 - Elsevier
Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-
dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron …

Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke

C Li, G Sun, B Chen, L Xu, Y Ye, J He, Z Bao… - Pharmacological …, 2021 - Elsevier
Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …