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Finding a way out: S1P signaling and immune cell migration
AAL Baeyens, SR Schwab - Annual review of immunology, 2020 - annualreviews.org
The signaling lipid sphingosine 1-phosphate (S1P) plays critical roles in an immune
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …
Getting in touch with mechanical pain mechanisms
The peripheral somatosensory system bestows mammals with a diverse repertoire of
sensory modalities: gentle touch, mechanical pain, itch, thermosensation, and …
sensory modalities: gentle touch, mechanical pain, itch, thermosensation, and …
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis
Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic
itch diseases are thought to be driven by both the nervous and immune systems, but the …
itch diseases are thought to be driven by both the nervous and immune systems, but the …
Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss
Pathological sensations caused by peripheral painful neuropathy occurring in Type 2
diabetes mellitus (T2DM) are often described as 'sharp'and 'burning'and are commonly …
diabetes mellitus (T2DM) are often described as 'sharp'and 'burning'and are commonly …
Optical control of sphingosine-1-phosphate formation and function
Abstract Sphingosine-1-phosphate (S1P) plays important roles as a signaling lipid in a
variety of physiological and pathophysiological processes. S1P signals via a family of G …
variety of physiological and pathophysiological processes. S1P signals via a family of G …
TRP channels as drug targets to relieve itch
Z ** non-narcotic pain therapeutics
Chronic pain is a life-altering condition affecting millions of people. Current treatments are
inadequate and prolonged therapies come with severe side effects, especially dependence …
inadequate and prolonged therapies come with severe side effects, especially dependence …
[HTML][HTML] Protocol for dissection and culture of murine dorsal root ganglia neurons to study neuropeptide release
In this protocol, we provide step-by-step instructions for dissection and culture of primary
murine dorsal root ganglia (DRG), which provide an opportunity to study the functional …
murine dorsal root ganglia (DRG), which provide an opportunity to study the functional …