Classically, the basal ganglia have been considered to have a role in producing habitual
and goal-directed behaviours. In this article, we review recent evidence that expands this …

Unexpected events are part of everyday experience. They come in several varieties—action
errors, unexpected action outcomes, and unexpected perceptual events—and they lead to …

Objectives Firstly, to identify subthalamic region stimulation clusters that predict maximum
improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and …

Although Parkinson's disease (PD) is primarily considered a disorder of initiation of actions,
patients also have deficits in inhibitory control, both in the motor and cognitive domains …

The subthalamic nucleus is part of a global stop** network that also includes the
presupplementary motor area and inferior frontal gyrus of the right hemisphere. In …

Subthalamic deep brain stimulation (STN-DBS) for Parkinson's disease treats motor
symptoms and improves quality of life, but can be complicated by adverse neuropsychiatric …

Molecular imaging has proven to be a powerful tool for investigation of parkinsonian
disorders. One current challenge is to identify biomarkers of early changes that may predict …

Deep brain stimulation of the subthalamic nucleus for Parkinson's disease is an established
advanced therapy that addresses motor symptoms and improves quality of life. However, it …

Inhibition of inappropriate, habitual or prepotent responses is an essential component of
executive control and a cornerstone of self-control. Via the hyperdirect pathway, the …

The aim of our study was to investigate two inter-related hypotheses about the role of the
subthalamic nucleus. First that the subthalamic nucleus plays a role in adjusting response …