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An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - benthamdirect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
iProt-Sub: a comprehensive package for accurately map** and predicting protease-specific substrates and cleavage sites
Regulation of proteolysis plays a critical role in a myriad of important cellular processes. The
key to better understanding the mechanisms that control this process is to identify the …
key to better understanding the mechanisms that control this process is to identify the …
iPromoter-2L: a two-layer predictor for identifying promoters and their types by multi-window-based PseKNC
B Liu, F Yang, DS Huang, KC Chou - Bioinformatics, 2018 - academic.oup.com
Motivation Being responsible for initiating transaction of a particular gene in genome,
promoter is a short region of DNA. Promoters have various types with different functions …
promoter is a short region of DNA. Promoters have various types with different functions …
[HTML][HTML] iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC
Abstract N 6-methyladenine (6mA) is one kind of post-replication modification (PTM or
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
iRNA-PseColl: identifying the occurrence sites of different RNA modifications by incorporating collective effects of nucleotides into PseKNC
There are many different types of RNA modifications, which are essential for numerous
biological processes. Knowledge about the occurrence sites of RNA modifications in its …
biological processes. Knowledge about the occurrence sites of RNA modifications in its …
SubMito-XGBoost: predicting protein submitochondrial localization by fusing multiple feature information and eXtreme gradient boosting
Motivation Mitochondria are an essential organelle in most eukaryotes. They not only play
an important role in energy metabolism but also take part in many critical cytopathological …
an important role in energy metabolism but also take part in many critical cytopathological …
2L-piRNA: a two-layer ensemble classifier for identifying piwi-interacting RNAs and their function
B Liu, F Yang, KC Chou - Molecular Therapy Nucleic Acids, 2017 - cell.com
Involved with important cellular or gene functions and implicated with many kinds of cancers,
piRNAs, or piwi-interacting RNAs, are of small non-coding RNA with around 19–33 nt in …
piRNAs, or piwi-interacting RNAs, are of small non-coding RNA with around 19–33 nt in …
[HTML][HTML] Pse-in-One 2.0: an improved package of web servers for generating various modes of pseudo components of DNA, RNA, and protein sequences
B Liu, H Wu, KC Chou - Natural science, 2017 - scirp.org
Pse-in-One 2.0 is a package of web-servers evolved from Pse-in-One (Liu, B., Liu, F., Wang,
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
iPTM-mLys: identifying multiple lysine PTM sites and their different types
Motivation: Post-translational modification, abbreviated as PTM, refers to the change of the
amino acid side chains of a protein after its biosynthesis. Owing to its significance for in …
amino acid side chains of a protein after its biosynthesis. Owing to its significance for in …
iRNA-3typeA: identifying three types of modification at RNA's adenosine sites
RNA modifications are additions of chemical groups to nucleotides or their local structural
changes. Knowledge about the occurrence sites of these modifications is essential for in …
changes. Knowledge about the occurrence sites of these modifications is essential for in …