The optimal treatment for complex fractures and large bone defects is an important unsolved
issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal …

Tissue engineering strategies for treating bone loss to date have largely focused on
targeting stem cells or vascularization. Immune cells, including macrophages and T cells …

Clinical studies, as well as in vitro and in vivo experiments have demonstrated that
byproducts from joint replacements induce an inflammatory reaction that can result in …

In this study, the regulatory role and mechanisms of tantalum (Ta) particles in the bone
tissue microenvironment are explored. Ta particle deposition occurs in both clinical samples …

The use of stem cells in regenerative medicine, including tissue engineering and
transplantation, has generated a great deal of enthusiasm. Mesenchymal stromal/stem cells …

Bone regeneration is a complex and well‐coordinated process that involves crosstalk
between immune cells and resident cells in the injury site. Transplantation of mesenchymal …

Introduction Periapical lesions are inflammatory diseases mainly caused by microbial
infection from the root canal system, affecting the integrity of alveolar bone, periapical …

Osteolysis is one of the most prominent reasons of revision surgeries in total joint
arthroplasty. This biological phenomenon is induced by wear particles and corrosion …

Osteonecrosis of the epiphyseal and metaphyseal regions of major weight-bearing bones of
the extremities is a condition that is associated with local death of bone cells and marrow in …

Background Mesenchymal stem cell (MSC)-based therapy has the potential for
immunomodulation and enhancement of tissue regeneration. Genetically modified MSCs …