Fear generalization and anxiety: behavioral and neural mechanisms

JE Dunsmoor, R Paz - Biological psychiatry, 2015 - Elsevier
Fear can be an adaptive emotion that helps defend against potential danger. Classical
conditioning models elegantly describe how animals learn which stimuli in the environment …

Fear generalization in humans: systematic review and implications for anxiety disorder research

S Dymond, JE Dunsmoor, B Vervliet, B Roche… - Behavior therapy, 2015 - Elsevier
Fear generalization, in which conditioned fear responses generalize or spread to related
stimuli, is a defining feature of anxiety disorders. The behavioral consequences of …

Neural circuits in anxiety and stress disorders: a focused review

ER Duval, A Javanbakht, I Liberzon - Therapeutics and clinical risk …, 2015 - Taylor & Francis
Anxiety and stress disorders are among the most prevalent neuropsychiatric disorders. In
recent years, multiple studies have examined brain regions and networks involved in anxiety …

Can anxiety damage the brain?

L Mah, C Szabuniewicz, AJ Fiocco - Current opinion in psychiatry, 2016 - journals.lww.com
Pathological anxiety and chronic stress lead to structural degeneration and impaired
functioning of the hippocampus and the PFC, which may account for the increased risk of …

Anxious brain networks: A coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety

J Xu, NT Van Dam, C Feng, Y Luo, H Ai, R Gu… - … & Biobehavioral Reviews, 2019 - Elsevier
Anxiety and anxiety disorders are associated with specific alterations to functional brain
networks, including intra-networks and inter-networks. Given the heterogeneity within …

Biological markers of generalized anxiety disorder

E Maron, D Nutt - Dialogues in clinical neuroscience, 2017 - Taylor & Francis
Generalized anxiety disorder (GAD) is a prevalent and highly disabling mental health
condition; however, there is still much to learn with regard to pertinent biomarkers, as well as …

Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder

RA Morey, JE Dunsmoor, CC Haswell… - Translational …, 2015 - nature.com
Fear conditioning is an established model for investigating posttraumatic stress disorder
(PTSD). However, symptom triggers may vaguely resemble the initial traumatic event …

A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward.

A Zugman, L Jett, C Antonacci, AM Winkler… - Journal of anxiety …, 2023 - Elsevier
Anxiety disorders are among the most prevalent psychiatric disorders. Neuroimaging
findings remain uncertain, and resting state functional magnetic resonance (rs-fMRI) …

Amygdala–prefrontal interactions in (mal) adaptive learning

E Likhtik, R Paz - Trends in neurosciences, 2015 - cell.com
The study of neurobiological mechanisms underlying anxiety disorders has been shaped by
learning models that frame anxiety as maladaptive learning. Pavlovian conditioning and …

[PDF][PDF] Map** compulsivity in the DSM-5 obsessive compulsive and related disorders: cognitive domains, neural circuitry, and treatment

NA Fineberg, AM Apergis-Schoute… - International Journal …, 2018 - academic.oup.com
Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm.
Growing evidence suggests that the neurocognitive mechanisms mediating behavioral …