Substance use disorders (SUD) are diseases of the brain, characterized by aberrant
functioning in the neural circuitry of the brain. Resting state functional connectivity (rsFC) can …

Baclofen, a GABA-B receptor agonist, is a promising treatment for alcohol use disorder
(AUD). Its mechanism of action in this condition is unknown. GABA-B receptors interact with …

Pain perception is decreased by shifting attentional focus away from a threatening event.
This attentional analgesia engages parallel descending control pathways from anterior …

The capacity to anticipate and detect rewarding outcomes is fundamental for the
development of adaptive decision‐making and goal‐oriented behavior. Delineating the …

Background Methamphetamine misuse, a surging cause of morbidity and mortality
worldwide, identifies Methamphetamine Use Disorder (MUD) as a critical public health …

Alcohol use disorder (AUD) alters decision-making control over actions, but disruptions to
the responsible neural circuit mechanisms are unclear. Premotor corticostriatal circuits are …

Background Drug addiction is associated with blunted neural responses to nondrug
rewards, such as money, but heightened responses to drug cues that predict drug-reward …

Abnormal resting‐state functional connectivity, as measured by functional magnetic
resonance imaging (MRI), has been reported in alcohol use disorders (AUD), but findings …

Mixed findings exist in studies comparing brain responses to reward in adolescents and
adults. Here we examined the trajectories of brain response, functional connectivity and task …

Naltrexone (NTX), a homolog of the opiate antidote naloxone, is an orally active long-acting
general opioid receptor antagonist used in the treatment of opiate dependence. NTX is also …